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182 次 病理靶點(diǎn)MLH1和NaPi2b/SLC34A2的主要功能和在癌癥診斷中的作用 2025-5-9
MLH1靶點(diǎn)簡(jiǎn)介MLH1（MutL Homolog 1）蛋白是一種在人類細(xì)胞中發(fā)現(xiàn)的DNA修復(fù)酶，屬于MutL蛋白家族。MLH1蛋白在DNA錯(cuò)配修復(fù)（Mismatch Repair, MMR）過(guò)程中起著關(guān)鍵作用，這一過(guò)程可以識(shí)別并修復(fù)DN
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187 次 運(yùn)動(dòng)減輕血流再循環(huán)激活代謝轉(zhuǎn)能器 SCD1 催化血管保護(hù)性代謝物 2025-5-7
Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolitesKS：Exercise；flow recirculation；SCD1作為對(duì)周期性心臟收縮的
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200 次 靶向軟骨下骨骨細(xì)胞中的H19用于減輕骨關(guān)節(jié)炎軟骨降解 2025-5-6
Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in OsteoarthritisKWS：LncRNA H19；Subchondral Bone Osteocytes；Cartilag
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247 次 內(nèi)皮雌激素-心肌cGMP軸決定壓力超負(fù)荷期間的血管生成和心臟功能 2025-4-28
Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overloadKeywords: Angiogenesis; Cycl
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288 次 鐵調(diào)素Hepcidin-25作為鐵代謝和免疫反應(yīng)關(guān)鍵調(diào)節(jié)因子的功能和作用 2025-4-28
在生命科學(xué)的探索中，Hepcidin-25（鐵調(diào)素，M28234，AbMole）作為鐵代謝和免疫反應(yīng)的關(guān)鍵調(diào)節(jié)因子，一直是研究的熱點(diǎn)。它不僅在基礎(chǔ)生物學(xué)中扮演著重要角色，還為理解生物體內(nèi)的復(fù)雜機(jī)制提供了新
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286 次 揭秘TH17細(xì)胞分化“開(kāi)關(guān)”：ChIP-seq 技術(shù)破解基因調(diào)控密碼 2025-4-27
2017年發(fā)表在Nature上的“Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation”的文章揭示了TGFβ的“反向調(diào)控”策略：正常
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288 次 機(jī)械拉伸誘導(dǎo)的活性氧驅(qū)動(dòng)新生豬腎上皮細(xì)胞內(nèi)皮素的產(chǎn)生 2025-4-27
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cellsKeywords: Acute kidney injury; Endothelin; Endothelin
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300 次 Hes1/Piezo1 通路在糖皮質(zhì)激素誘導(dǎo)的骨質(zhì)疏松癥中的關(guān)鍵作用 2025-4-22
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosisKeywords: Bone biology; Bone disease; Osteoporosis; Therapeutics.糖皮質(zhì)激素
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302 次 大腦通過(guò) PGE2 骨內(nèi)感受調(diào)節(jié)負(fù)重骨：踝關(guān)節(jié)骨性關(guān)節(jié)炎和疼痛的影響 2025-4-21
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and painSubject terms: Bone, Pathogenesis內(nèi)感受（Interoception）是一種監(jiān)
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359 次 Piezo1 介導(dǎo)的星狀細(xì)胞活化導(dǎo)致小鼠壓力誘導(dǎo)的胰腺纖維化 2025-4-15
Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in miceKeywords: Fibrosis; Gastroenterology.慢性胰腺炎是一種胰腺組織進(jìn)行性炎癥性疾病，其特征是產(chǎn)
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303 次 Piezo1 通道調(diào)控結(jié)膜上皮細(xì)胞 IL表達(dá):機(jī)械應(yīng)力與眼部炎癥關(guān)聯(lián)研究 2025-4-14
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammationKeywords: CREB; Conjunctival epithe
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273 次 糖苷內(nèi)切酶H從蛋白質(zhì)糖基化分析到蛋白質(zhì)折疊應(yīng)用 2025-4-8
糖苷內(nèi)切酶H（Endoglycosidase H，Endo H）是一種特異性識(shí)別和切割N-連接寡糖的內(nèi)切糖苷酶。它在糖生物學(xué)、蛋白質(zhì)組學(xué)、生物制藥等領(lǐng)域具有廣泛的研究和應(yīng)用價(jià)值。下面我將詳細(xì)介紹Endo H的研究
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387 次 骨肉瘤與巨噬細(xì)胞相互作用的IL-8經(jīng) FAK 促進(jìn)瘤生長(zhǎng)轉(zhuǎn)移 2025-4-8
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathwaySubject terms: Bone
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394 次 NETosis 驅(qū)動(dòng)高血壓患者血壓升高和血管功能障礙 2025-4-7
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in HypertensionKeywords: extracellular traps; histones; hypertension; neutrophils; protein-arginine deiminase type
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330 次 微生理系統(tǒng)產(chǎn)生的剪切力可減少關(guān)節(jié)炎3D模型中TNF-α介導(dǎo)的軟骨損傷 2025-4-1
Microphysiological System-Generated Physiological Shear Forces Reduce TNF-α-Mediated Cartilage Damage in a 3D Model of ArthritisKeywords: TNF‐α; articular cartilage br
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374 次 牙髓干細(xì)胞調(diào)節(jié)真皮成纖維細(xì)胞的炎癥小體通路和膠原沉積 2025-3-31
Dental Pulp Stem Cells Modulate Inflammasome Pathway and Collagen Deposition of Dermal FibroblastsKeywords: dental pulp stem cells; fibroblasts; fibrosis; inflammasome; inflammatio
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200 次 Tenascin-X 介導(dǎo)血流誘導(dǎo)的 EndMT 和動(dòng)脈粥樣硬化抑制 2025-3-25
Tenascin-X Mediates Flow-Induced Suppression of EndMT and AtherosclerosisKeywords: atherosclerosis; carotid arteries; endothelium; hemodynamics; inflammation; transforming growth f
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287 次 芥菜籽過(guò)敏原 Sina1 激活腸上皮細(xì)胞與樹突狀細(xì)胞 2025-3-24
Mustard seed major allergen Sin a1 activates intestinal epithelial cells and also dendritic cells that drive type 2 immune responsesKWS：Mustard seed；Sin a1；intestinal epithelial
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180 次 動(dòng)脈粥樣硬化和內(nèi)皮機(jī)械轉(zhuǎn)導(dǎo) 2025-3-17
Atherosclerosis and endothelial mechanotransduction: current knowledge and models for future researchKeywords: atherosclerosis; endothelial cell glycocalyx; mechanotransduction; sh
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335 次 HEG1 通過(guò)調(diào)節(jié)內(nèi)皮細(xì)胞中KLF2/4 表達(dá)來(lái)預(yù)防動(dòng)脈粥樣硬化 2025-3-17
HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial CellsKeywords: KLF2/4; atherosclerosis; endothelial cells; heart-of-glass 1
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