第二屆廣州核酸國際論壇 議程盛大公布
主題：Nucleic Acids Translational Research & Therapeutics (siRNA, miRNA, lncRNA, antisense, CRISPR)
第二屆廣州核酸國際論壇（CNAF）以核酸轉化研究與治療為主題，旨在推動核酸研究和治療藥物的發展，加強中國與國際的交流合作，促進中國核酸生物產業的進步，展望核酸技術作為創新藥物第三大發展引擎的美好前景。
本屆論壇特邀20多位國際頂級科學家和企業家參會演講，嘉賓囊括諾貝爾獎得主、世界百強藥企的高級主管、世界頂級學府的著名教授、核酸制藥上市公司的總裁、核酸治療世界聯盟主席等，內容涵蓋RNAi、microRNA、lncRNA、antisense、mRNA、exon-skipping、CRISPR等核酸技術最新進展，包括從核酸基礎研究到產業化，從臨床前開發到臨床研究，并分享去年世界首個核酸藥物成功上市的經驗。論壇的召開，將為國內科學家及研究生提供與本領域學術權威面對面交流的難得機會，為國內從事生物制藥的企業單位提供與世界知名藥企建立合作的紐帶。
我們期待與您相聚美麗羊城，共同迎接核酸治療時代的來臨！
主辦單位：專家聯誼會生物醫藥和生命科學專業委員會
中國生化與分子生物學會核糖核酸專業委員會
中國科學院廣州生物醫藥與健康研究院
呼吸疾病國家重點實驗室
中山大學
承辦單位：廣州市銳博生物科技有限公司
開幕主旨演講
Craig Mello教授
美國麻省大學醫學院教授
2006年諾貝爾生理學或醫學獎獲得者
主旨演講
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Troels Koch博士
丹麥Santaris / Roche制藥公司首席技術官，研發副總裁
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Ekkehard Leberer教授
法國賽諾菲研發聯盟管理高級總監, IMI COMPACT Consortium常務董事
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Muthiah Manoharan博士
美國Alnylam制藥公司高級副總裁，新藥開發負責人
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Brett Monia博士
美國Isis 制藥公司高級副總裁
Oligonucleotide Therapeutics Society當選主席
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大會擬定議程
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Wed, Nov 5, 2014
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Registration 13:00-18:00
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Thu, Nov 06, 2014 (Day 1)
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Chair
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Mano Manoharan, PhD Senior Vice President, Alnylam Pharmaceuticals, USA
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08:30-08:45
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Introduction
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CNAF Organizing Committee
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08:45-09:30
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Opening Keynote
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Craig Mello, PhD Professor, University of Massachusetts Medical School, HHMI, 2006 Nobel Prize Winner, USA
Title: RNA-guided genome defense and new frontiers in biotech and medicine
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09:30-10:10
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Keynote
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Brett Monia, PhD Senior Vice President, Isis Pharmaceuticals, OTS President, USA
Title: Transforming drug discovery for human therapeutics with antisense technology
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10:10-10:35
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Plenary
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Judy Lieberman, MD, PhD Professor, Program Chair, Harvard Medical School, USA
Title: Targeted gene knockdown to treat cancer
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10:35-10:55
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Tea Break
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10:55-11:20
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Plenary
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Matthew Porteus, MD, PhD Professor, Stanford School of Medicine, CRISPR Therapeutics Founder, USA
Title: Genome editing using engineered nucleases
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11:20-11:45
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Plenary
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Erwei Song, MD, PhD Professor and Vice Dean, Sun Yat-Sen Memorial Hospital, China
Title: BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
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11:45-12:00
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Technology
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Rick Hogrefe, PhD Founder, President and Chief Executive Officer, TriLink BioTechnologies
Title: Designing a mRNA therapeutic suitable for scale up
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12:00-13:30
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Lunch
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13:30-13:35
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Chair
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Brett Monia, PhD Senior Vice President, Isis Pharmaceuticals, OTS President, USA
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13:35-14:15
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Keynote
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Troels Koch, PhD Senior Vice President and Chief Technology Officer, Santaris / Roche, Denmark
Title: LNA antisense – concepts & status
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14:15-14:40
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Plenary
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Dmitry Samarsky, PhD Executive Vice President, Technology Development, RiboBio, China
Title: In vivo delivery of therapeutic oligonucleotides and potential applications for cancer
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14:40-15:05
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Plenary
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Georg Sczakiel, PhD Professor, University of Lübeck, Germany
Title: Target RNA is involved in guide strand loading of Argonaute-2 and siRNA-induced RNA interference
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15:05-15:25
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Tea Break
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15:25-15:50
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Plenary
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Peixuan Guo, PhD Professor, William S. Farish Fund Endowed Chair, University of Kentucky, USA
Title: A new generation of drugs from the emerging field of RNA nanotechnology
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15:50-16:15
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Plenary
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Yi Jin, PhD Executive Vice President, Suzhou Ribo Life Science, China
Title: RNAi based therapeutics for Hepatitis B
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16:15-16:30
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Technology
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Suresh Srivastava, PhD Founder and President, ChemGenes, USA
Title: BMEG oligonucleotides for efficient cellular delivery for therapeutic and molecular biological applications
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16:30-16:55
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Plenary
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David Lewis, PhD Chief Scientific Officer, Arrowhead Research Corporation, USA
Title: Using Dynamic Polyconjugate® (DPC) technology to advance RNAi-based therapeutics
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16:55-17:00
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Day End
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CNAF Organizing Committee
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Fri, Nov 07, 2014 (Day 2)
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09:00-09:05
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Chair
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Troels Koch, PhD Senior Vice President and Chief Technology Officer, Santaris / Roche, Denmark
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09:05-09:45
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Keynote
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Ekkehard Leberer, PhD Professor, Senior Director of R&D Alliance Management, Sanofi, Germany
Title: Nucleic acid therapeutics: opportunities and challenges for innovation in drug development
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09:45-10:10
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Plenary
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William Marshall, PhD President and Chief Executive Officer, Board Director, miRagen Therapeutics, USA
Title: Discovery and development of microRNA targeting therapeutics
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10:10-10:35
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Plenary
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Micky Tortorella, PhD Chief Technology Officer and Vice President for Drug Discovery and Technology Transfer, Guangzhou Institutes of Biomedicine and Health, China
Title: Intra-articular delivery of siRNA-conjugates as new disease modifying osteoarthritis drugs
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10:35-10:55
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Tea Break
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10:55-11:20
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Plenary
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Chengyu Jiang, PhD Professor, Chair, Peking Union Medical College, CAMS, China
Title: Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro
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11:20-11:45
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Plenary
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Marc Lemaitre, PhD Chief Executive Officer, Sirnaomics, USA / China
Title: Improving siRNA therapeutics using polymer-nanoparticle (PNP) delivery: recent pre-clinical results with STP705 against skin scars
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11:45-12:00
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Technology
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Kimo Sanderson Vice President, Asahi Kasei, Japan
Title: Therapeutic oligonucleotides from discovery to development: the importance of proper production and scale up
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12:00-13:30
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Lunch
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13:30-13:35
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Chair
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William Marshall, PhD President, Chief Executive Officer, Board Director, miRagen Therapeutics, USA
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13:35-14:15
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Keynote
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Mano Manoharan, PhD Senior Vice President, Alnylam Pharmaceuticals, USA
Title: Chemical strategies for systemic delivery of RNAi drugs
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14:15-14:40
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Plenary
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Dirk Haussecker, PhD Founder and Curator, RNAi Therapeutics Blog, Germany
Title: RNA therapeutics emerging as major drug discovery engine
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14:40-15:05
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Plenary
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TBD
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15:05-15:20
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Technology
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Carina Andersson, PhD Marketing Head, GE, USA
Title: A manufacturing solution of oligonucleotides
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15:20-15:40
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Tea Break
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15:40-16:05
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Plenary
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Sven Klussmann, PhD Chief Scientific Officer, NOXXON Pharma, Germany
Title: From bench to bedside – the conversion of mirror-image oligonucleotides into therapeutics
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16:05-16:30
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Plenary
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Ryszard Kole, PhD Distinguished Scientist, Professor, Sarepta Therapeutics, USA
Title: Eteplirsen, a phosphorodiamidate morpholino oligonucleotide, as treatment for Duchenne muscular dystrophy (DMD)
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16:30-16:55
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Plenary
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René Thürmer, PhD Deputy Head of the Unit Pharmaceutical Biotechnology, BfArM - Federal Institute for Drugs and Medical Devices, Germany
Title: Regulatory aspects of nucleic acids therapeutics
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16:55-17:15
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Closing Remarks
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Craig Mello, PhD Professor, University of Massachusetts Medical School, HHMI, 2006 Nobel Prize Winner, USA
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會議時間：2014年11月5-7日
會議地點：廣州科學城翡翠皇冠假日酒店
會議語言：英語
論壇網站：www.cnaf.org.cn（點此注冊）
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