Synonyms :

IL-1Ra, ICIL-1RA, IRAP, IL-1RN

Description :

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant human IL-1Ra is a 17.2 kDa protein consisting of 153 amino acid residues.

Catalog #:

200-01RA

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :

Determined by its ability to inhibit the IL-1alpha stimulation of murine D10S cell. The expected ED ₅₀ is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.

Selected References :

Selected List of References Citing This Product

AA Sequence :

MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

PubMed Link :

IL-1Ra

Country of Origin :

USA

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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.