Synonyms :
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B-TCGF, CSIF, TGIF
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Description :
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IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues.
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Catalog #:
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200-10
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED
50
was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105
units/mg.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
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PubMed Link :
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IL-10
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Country of Origin :
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USA
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| Size A
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2µg
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$80
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| Size B
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10µg
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$195
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| Size C
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1mg
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$5200
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Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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