Synonyms :
|
Soluble Tumor Necrosis Factor type II, TNFRSF1B, TNFR75, p75, CD120b, TNFR80, p80
|
Description :
|
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein.
|
Catalog #:
|
310-12
|
Source :
|
E.coli
|
Purity :
|
Greater than 98% by SDS-PAGE gel and HPLC analyses.
|
Endotoxin Level :
|
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
|
Biological Activity :
|
Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED
50
for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.125 µg/ml.
|
Selected References :
|
Selected List of References Citing This Product
|
AA Sequence :
|
MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP
|
PubMed Link :
|
TNF+AND+Receptor-2
|
Country of Origin :
|
USA
|
|
|
|
|
| Size A
|
5µg
|
$80
|
|
| |
| Size B
|
20µg
|
$195
|
|
| |
| Size C
|
1mg
|
$3000
|
|
| |
|
|
|
|
Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
|
|
Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
|
