Synonyms :

Growth/Differentiation Factor-3

Description :

GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.

Catalog #:

120-22

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μ</>g (1EU/μ</>g).

Biological Activity :

Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED ₅₀ for this effect is 100-150 ng/ml.

AA Sequence :

AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG

PubMed Link :

GDF-3+OR+GDF3

Country of Origin :

USA

Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.

Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.