Synonyms :
|
Brain Derived Neurotrophic Factor
|
Description :
|
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
|
Catalog #:
|
450-02
|
Source :
|
E.coli
|
Purity :
|
Greater than 98% by SDS-PAGE gel and HPLC analyses.
|
Endotoxin Level :
|
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
|
Biological Activity :
|
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
|
Selected References :
|
Selected List of References Citing This Product
|
AA Sequence :
|
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
|
PubMed Link :
|
BDNF+AND+human
|
Country of Origin :
|
USA
|
|
|
|
|
| Size A
|
2µg
|
$80
|
|
| |
| Size B
|
10µg
|
$195
|
|
| |
| Size C
|
1mg
|
$5200
|
|
| |
|
|
|
|
Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
|
|
Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
|
