Synonyms :
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soluble TRAIL Receptor-2, DR5, TNFRSF10B, KILER, TRICK2A, TRICKB
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Description :
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TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
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Catalog #:
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310-19
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L. 50% inhibition (100 ng/ml of sTRAIL/Apo2L) was reached using a concentration of 1000 ng/ml of sTRAIL Receptor-2.
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AA Sequence :
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MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES
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PubMed Link :
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TRAIL+AND+Receptor+AND+DR5
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Country of Origin :
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USA
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| Size A
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10µg
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$80
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| Size B
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50µg
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$195
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| Size C
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1mg
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$1500
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Special Sizes:
Many products can be ordered in custom sizes. Please click here
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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