Synonyms :
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Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin
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Description :
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Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
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Catalog #:
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300-42
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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ACYCRIPACI AGERRYGYCI YQGRLWAFCC
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PubMed Link :
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NP-1+AND+human+AND+defensin
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Country of Origin :
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USA
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| Size A
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5µg
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$80
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| Size B
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20µg
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$195
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| Size C
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1mg
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$3000
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Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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