Synonyms :
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Fms-related tyrosine kinase 3 ligand
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Description :
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Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand has no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues.
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Catalog #:
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250-31L
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analyses
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per μg (1EU/μg).
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Biological Activity :
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Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED
50
for this effect is 5.0 – 8.0 ng/ml.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ
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PubMed Link :
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flt-3-ligand+AND+mouse
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Country of Origin :
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USA
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| Size A
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2µg
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$80
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| Size B
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10µg
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$195
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| Size C
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1mg
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$3900
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Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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