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重組人GDNF 500ug
英文名稱:Recombinant Human GDNF總訪問(wèn):509
國(guó)產(chǎn)/進(jìn)口:進(jìn)口半年訪問(wèn):13
產(chǎn)地/品牌:美國(guó)/PeproTech產(chǎn)品類別:細(xì)胞生物學(xué)試劑
規(guī)       格:500ug 最后更新:2025-5-14
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名稱:重組人GDNF
產(chǎn)品貨號(hào):450-10
規(guī)格:500ug
產(chǎn)地:美國(guó)
品牌商標(biāo):PeproTech
供應(yīng)商:PeproTech(派普泰克)
數(shù)量:大量
英文名:Recombinant Human GDNF

Synonyms :

Glial-Derived Neurotrophic Factor, ATF-1

Description :

GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Catalog #:

450-10

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

The ED 50 was determined by the proliferation of rat C6 cells is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.

Selected References :

Selected List of References Citing This Product

AA Sequence :

MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI

PubMed Link :

GDNF+AND+human

Country of Origin :

USA


Size A 2µg $80   
 
Size B 10µg $195   
 
Size C 1mg $5200   
 


Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact with your request.

Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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