Synonyms :
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TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand, TL2
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Description :
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TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein.
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Catalog #:
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310-04
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Source :
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E.coli
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Purity :
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Greater than 98% by SDS-PAGE gel and HPLC analysis.
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Endotoxin Level :
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Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Biological Activity :
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Assay#1:
Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED
50
for this effect is 1.0-3.0 ng/ml.
Assay#2:
Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED
50
for this effect is 0.8 - 2.0 ng/ml.
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Selected References :
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Selected List of References Citing This Product
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AA Sequence :
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MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG
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PubMed Link :
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TRAIL+AND+TNF
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Country of Origin :
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USA
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| Size A
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10µg
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$80
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| Size B
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50µg
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$195
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| Size C
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1mg
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$1500
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Special Sizes:
Many products can be ordered in custom sizes. Please click here
to contact with your request.
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Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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